C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/506 (2006.01) A61K 45/06 (2006.01) C07C 275/06 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2489128
The present invention relates to compounds of formula I, wherein X, Q, W, R1, R2 and R3 are as defined in the claims, which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in, mammals. The present invention also relates to a method for preparing these compounds.
L'invention concerne des composés de formule I, dans laquelle X, Q, W, R?1¿, R?2¿ et R?3 ¿sont tels que définis dans les revendications. Ces composés inhibent la gyrase bactérienne et/ou la topoisomérase IV. L'invention concerne également des compositions acceptables sur le plan pharmaceutique comprenant ces composés. Ces composés et compositions sont utiles pour le traitement d'infections bactériennes. Par conséquent, l'invention concerne également des méthodes de traitement d'infections bactériennes chez des mammifères. L'invention concerne enfin un procédé de préparation de ces composés.
Charifson Paul
Deininger David D.
Drumm Joseph
Grillot Anne-Laure
Liao Yusheng
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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