Triamine derivative

Details Triamine derivative Triamine derivative

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4545 (2006.01) A61K 31/4725 (2006.01) A61K 31/5377 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2602228

A novel compound having a strong FXa inhibiting potency and capable of exhibiting an excellent antithrombotic effect through oral administration. There are provided compounds of the general formula: (1) wherein each of R1 and R2 independently is a hydrogen atom, hydroxyl, an alkyl or an alkoxy; Q1 is an optionally substituted saturated or unsaturated bicyclic or tricyclic condensed hydrocarbon group or an optionally substituted saturated or unsaturated bicyclic or tricyclic condensed heterocyclic group, etc.; Q2 is a single bond, a linear or branched C1-C6 alkylene, a linear or branched C2-C6 alkenylene, etc.; each of R3 and R4 is an alkyl, etc.; each of m and n is a number of 0 to 3; Q4 is an aryl; and each of T0 and T1 is carbonyl, etc., and provided pharmaceuticals comprising any of the compounds.

Nouveau composé ayant une forte activité d'inhibition du facteur FXa et capable de présenter un excellent effet antithrombotique via une administration orale. L'invention concerne des composés de formule générale : (1) où chacun de R1 et R2 est indépendamment un atome d'hydrogène, un hydroxyle, un alkyle ou un alcoxy ; Q1 est un groupe hydrocarboné condensé bicyclique ou tricyclique saturé ou insaturé facultativement substitué ou un groupe hétérocyclique condensé bicyclique ou tricyclique saturé ou insaturé facultativement substitué, etc. ; Q2 est une simple liaison, un alkylène en C1-C6 linéaire ou ramifié, un alcénylène en C2-C6 linéaire ou ramifié, etc. ; chacun de R3 et R4 est un alkyle, etc. ; chacun de m et n est un nombre de 0 à 3 ; Q4 est un aryle ; et chacun de T0 et T1 est un carbonyle, etc. et l'invention concerne également des produits pharmaceutiques comprenant l'un quelconque des composés.

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