G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/00 (2006.01) A61K 49/00 (2006.01) C07K 14/72 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2422921
The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.
L'invention concerne des souris présentant une activité réduite du récepteur CAR et des souris exprimant un récepteur CAR humain. Ces souris conviennent pour des méthodes de criblage permettant d'identifier des composés qui modulent l'activité du récepteur CAR, des composés susceptibles de présenter une toxicité induite par CAR et des analogues desdits composés présentant une toxicité potentielle moindre.
Chua Steven S.
Moore David D.
Wei Ping
Baylor College Of Medicine
Borden Ladner Gervais Llp
LandOfFree
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