C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/22 (2006.01) C12N 15/10 (2006.01) C12N 15/55 (2006.01) C12N 15/64 (2006.01) C12N 15/79 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2625774
A LAGLIDADG homing endonuclease variant, having mutations in two separate subdomains, each binding a distinct part of a modified DNA target half-site, said LAGLIDADG homing endonuclease variant being able to cleave a chimeric DNA target sequence comprising the nucleotides bound by each subdomain. Use of said herodimeric meganuclease and derived products for genetic engineering, genome therapy and antiviral therapy.
La présente invention concerne une variante de l~endonucléase ciblée LAGLIDADG qui présente des mutations dans deux sous-domaines séparés, chacun liant une partie distincte d~un demi-site cible d~ADN modifié, ladite variante de l~endonucléase ciblée LAGLIDADG étant capable de cliver une séquence cible d~ADN chimère contenant les nucléotides liés par chaque sous-domaine. L~invention a également pour objet l~utilisation de ladite méganucléase héterodimérique et de produits dérivés destinés au génie génétique, la thérapie génique et la thérapie antivirale.
Cellectis
Robic
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