Methods of promoting the differentiation of stem cells

Details Methods of promoting the differentiation of stem cells Methods of promoting the differentiation of stem cells

A - Human Necessities

61

K

A61K 38/18 (2006.01) C12N 5/077 (2010.01) C12N 5/079 (2010.01) A61K 35/30 (2006.01) A61K 35/34 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2520629

A method is described by which stem cells are induced to differentiate into cardiomyocytes; the method comprises exposure for a length of time and at efficacious quantities of a protein of the EGF-CFC family or its derivatives having at least the EGF and CFC domains; or to differentiate into neuronal cells, comprising the exposure to Cripto protein inhibitors. Compositions are described for therapeutic use in treating heart disorders, comprising a therapeutically efficacious quantity of a protein or its derivatives having at least the EGF and CFC domains of a protein of the EGF-CFC family.

L'invention concerne une méthode permettant la différenciation de cellules souches en cardiomyocytes. Ladite méthode consiste à exposer pendant un certain temps et en quantités efficaces une protéine de la famille EGF-CFC ou ses dérivés possédant au moins les domaines EGF et CFC ; ou à différencier en cellules neuronales, y compris par l'exposition d'inhibiteurs de la protéine Cripto. L'invention porte également sur des compositions à usage thérapeutique dans le traitement de troubles du coeur, comprenant une quantité efficace au plan thérapeutique d'une protéine ou d'un de ses dérivés possédant au moins le domaine EGF et CFC d'une protéine de la famille EGF-CFC.

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