Preparation and utility of substituted carboxylic acid...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 57/32 (2006.01) A61K 31/192 (2006.01) C07B 59/00 (2006.01) C07C 59/64 (2006.01)

Patent

CA 2653262

The present disclosure is directed to modulators of cyclooxygenase (COX) enzymes and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of non-specific pain, tension-type pain, headache, migraine, lower back pain, sciatica, dental pain, muscular pain, pain associated with acute soft tissue injuries, bursitis, tendonitis, lumbago, periarthritis, tennis elbow, sprains, strains, muscular problems associated with sports injuries, muscular problems associated with accidents, period pain, primary dysmenorrhoea, acute sore throat pain, osteoarthritis, rheumatoid arthritis, cancer, any disorder requiring analgesic response, any disorder requiring anti- inflammatory response, any disorder requiring antipyretic response, any conditions mediated by cyclooxygenase, cystic fibrosis, dementia, Alzheimer's disease, and/or conditions mediated by levels of .beta.-amyloid are described.

La présente invention concerne des modulateurs des enzymes cyclooxygénases (COX) et des sels et des promédicaments pharmaceutiquement acceptables de ceux-ci, leur synthèse chimique ainsi que l'utilisation médicale de ces composé pour traiter et/ou gérer l'intensité et la durée de la douleur non spécifique, de la douleur de type tension, de la céphalée, de la migraine, de la lombalgie, de la sciatique, de la douleur dentaire, de la douleur musculaire, de la douleur associée à des lésions aiguës du tissu mou, de la bursite, de la tendinite, du lumbago, de la périarthrite, de l'épicondylite latérale, des entorses, des problèmes musculaires associés aux traumatismes sportifs, des problèmes musculaires associés aux accidents, de la douleur périodique, de la dysménorrhée primaire, du mal de gorge aigu, de l'ostéoarthrite, de l'arthrite rhumatoïde, du cancer, d'un trouble quelconque nécessitant une réponse analgésique, d'un trouble quelconque nécessitant une réponse anti-inflammatoire, d'un trouble quelconque nécessitant une réponse antipyrétique, d'affections quelconques médiées par la cyclooxygénase, de la mucoviscidose, de la démence, de la maladie d'Alzheimer et/ou d'affections médiées par les taux de .beta.-amyloïde.

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