Pyrimidine-2,4,6-trione metalloproteinase inhibitors

Details Pyrimidine-2,4,6-trione metalloproteinase inhibitors Pyrimidine-2,4,6-trione metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/60 (2006.01) A61K 31/513 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2381551

The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of formula (I) wherein X, Y, Ar1, Z, R1, R2 and R3 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

La présente invention concerne des inhibiteurs de pyrimidine-2,4,6-trione métalloprotéinase selon la formule (I), où X, Y, Ar?1¿, Z, R?1¿, R?2¿ et R?3¿ sont tels que définis dans le descriptif. L'invention traite également de compositions pharmaceutiques et de procédés de traitement de l'inflammation, du cancer et d'autres troubles.

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