Peptide inhibitors of cd40l signaling and uses therefor

Details Peptide inhibitors of cd40l signaling and uses therefor Peptide inhibitors of cd40l signaling and uses therefor

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 7/04 (2006.01) A61P 29/00 (2006.01) C07K 14/195 (2006.01) C07K 14/37 (2006.01) C07K 14/405 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2730316

The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signaling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particular-ly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulato-ry pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.

La présente invention porte sur des compositions comprenant des inhibiteurs peptidiques de la signalisation dépendante de CD40L qui ne sont pas issus d'un partenaire de liaison naturel de CD40L tel que CD40 ou d'une interface CD40-CD40L native. Plus particulièrement, les inhibiteurs peptidiques de la présente invention sont issus de sources naturelles qui n'expriment pas de voies costimulatrices CD40-CD40L. L'invention porte également sur des dérivés synthétiques et des analogues des inhibiteurs peptidiques ayant une affinité de liaison accrue pour CD40L ou une activité d'inhibition accrue par rapport à leurs molécules parentes.

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