Tricyclic diazepines as tocolytic oxytocin receptor antagonists

Details Tricyclic diazepines as tocolytic oxytocin receptor antagonists Tricyclic diazepines as tocolytic oxytocin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61P 25/18 (2006.01) C07D 487/14 (2006.01)

Patent

CA 2443490

This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist acivity, including treatment of preterm labor, dysmerorrhea, endometritis, and for suppressing labor prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

La présente invention concerne de nouveaux composés de diazépine tricyclique ainsi que des méthodes et des compositions pharmaceutiques faisant appel auxdits composés afin de traiter et/ou de prévenir et/ou de supprimer des troubles pouvant être soignés ou atténués par l'activité d'antagonistes de l'oxytocine parmi lesquels figurent les contractions prématurées, la dysménorrhée, l'endométrite, ou pour supprimer le travail précédent un accouchement par césarienne. Lesdits composés peuvent en outre servir à améliorer les taux de fertilité et de survie ainsi qu'à synchroniser l'oeustrus chez les animaux de ferme. Par ailleurs, ces composés peuvent être utilisés dans le cadre de la prévention et du traitement de dysfonctionnements du système de l'oxytocine dans le système nerveux central, y compris du trouble obsessionnel-compulsif et d'autres troubles neuropsychiatriques.

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