Simian-human hav having a chimeric 2c protein

Details Simian-human hav having a chimeric 2c protein Simian-human hav having a chimeric 2c protein

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 31/70 (2006.01) A61K 39/125 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) A61K 48/00 (2006.01) C07K 14/10 (2006.01) C07K 16/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2251832

The present invention discloses simian-human hepatitis A virus chimeric genomes which encode a hepatitis A virus having a chimeric 2C protein. The invention further discloses the use of these viruses or the nucleic acid sequence encoding them as vaccines.

L'invention concerne des génomes chimères du virus de l'hépatite A chez l'homme et chez le singe qui codent un virus de l'hépatite A ayant une protéine 2C chimère. Elle porte aussi sur l'utilisation en tant que vaccins desdits virus ou des séquences nucléotidiques qui les codent.

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