Npc1l1 and npc1l1 inhibitors and methods of use thereof

Details Npc1l1 and npc1l1 inhibitors and methods of use thereof Npc1l1 and npc1l1 inhibitors and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2579790

The present invention provides a novel gene, designated herein as ~NPC1L1~, that is associated with lipid or glucose metabolism. The invention further provides the use of the NPC1L1 gene and its corresponding protein to diagnose a lipid condition in a cell or tissue and to screen for novel therapeutic compounds useful for treating lipid disorders and other NPC1L1-associated or mediated diseases or disorders. The invention further provides specific inhibitors of NPC1L1.

L'invention se rapporte à un nouveau gène, désigné ci-après parNPC1L1 , qui est associé au métabolisme lipidique ou de glucose. L'invention porte aussi sur l'utilisation du gène NPC1L1 et de sa protéine correspondante afin de diagnostiquer une condition lipidique dans une cellule ou un tissu et afin de procéder au criblage pour trouver de nouveaux composés thérapeutiques en vue de traiter des troubles lipidiques et d'autres maladies ou troubles associés à NPC1L1 ou à médiation de NPC1L1. Cette invention porte aussi sur des inhibiteurs particuliers de NPC1L1.

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