Novel human anti-r7v antibodies and uses thereof

Details Novel human anti-r7v antibodies and uses thereof Novel human anti-r7v antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2681130

The present application relates to novel human antibodies capable of binding specifically to the R7V epitope of HIV. These antibodies have all human CDR and are capable of specifically neutralizing all strains of HIV, including escape mutants. These antibodies are useful for the treatment of HIV infection, especially in patients in failure of HAART.

La présente invention porte sur de nouveaux anticorps humains capables de se lier de façon spécifique à l'épitope R7V du VIH. Ces anticorps ont toutes les CDR humaines et sont capables de neutraliser de façon spécifique toutes les souches de HIV, comprenant les mutants d'échappement. Ces anticorps sont utiles pour le traitement d'une infection par le VIH, en particulier dans des patients en échec de HAART.

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