Thiazoline acid derivatives

Details Thiazoline acid derivatives Thiazoline acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/12 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) C07D 277/10 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2250243

2-(2-Hydroxy aryl)-thiazoline-4-carboxylic acids and derivatives are useful as chelators of trivalent metals in therapeutic applications. These thiazoline acid derivatives include compounds of the formula; (see formula I, II, III) Image wherein: R is H or acyl; R1, R2, R3, R4 and R7 are the same or different and represent H, alkyl or hydrocarbyl arylalkyl having up to 14 carbon atoms, or Image , wherein x is 1-10 and y is 0-10; R5 is H, alkyl having up to 15 carbon atoms, Image wherein x is 1-10 and y is 0-10, or Image wherein R1 is as defined above, z is 1-10 arid q is 0-5; R6 is H or acyl; n is 0-10; excluding those compounds of formula II: (a) wherein n = 0, R6 is H and R5 is CH3; and (b) wherein n = 0, R6 is H and R5 is Image a salt thereof with a pharmaceutically acceptable acid or a pharmaceutically acceptable complex thereof.

L'invention a pour objet des acides 2-(2-hydroxy aryl)-thiazoline-4-carboxyliques et leurs dérivés, qui sont utiles comme chélatants de métaux trivalents dans des applications thérapeutiques.

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