Human calcium channel compositions and methods

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2113203

Isolated DNA encoding each of human calcium channel .alpha.1-, .alpha.2-, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.

Est décrit un ADN isolé codant pour chacune des sous-unités alpha1-, alpha2-, beta- et gamma de canaux calciques humains, notamment des sous-unités qui apparaissent sous forme de variantes d'épissage de transcrits primaires. Sont également décrits des cellules et des vecteurs renfermant l'ADN et des procédés pour identifier des composés qui modulent l'activité des canaux calciques humains.

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