Novel polypeptides for promoting cell attachment

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 38/39 (2006.01) A61K 39/395 (2006.01) A61L 27/00 (2006.01) C07K 14/435 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/02 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2125174

Novel polypeptides derived from human fibronectin, and fusion proteins containing those peptide sequences are describes which define a receptor binding site on fibronectin that binds to the platelet receptor glycoprotein GPIIb-IIIa expressed by cells. The receptor binding site of human fibronectin includes at least fibronectin amino acid residues 1410-1436. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors preparing the fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.

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