C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 38/39 (2006.01) A61K 39/395 (2006.01) A61L 27/00 (2006.01) C07K 14/435 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/02 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2125174
Novel polypeptides derived from human fibronectin, and fusion proteins containing those peptide sequences are describes which define a receptor binding site on fibronectin that binds to the platelet receptor glycoprotein GPIIb-IIIa expressed by cells. The receptor binding site of human fibronectin includes at least fibronectin amino acid residues 1410-1436. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors preparing the fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.
Bowditch Ronald
Ginsberg Mark H.
Plow Edward F.
Fetherstonhaugh & Co.
The Scripps Research Institute
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