A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/87 (2006.01) A61P 9/12 (2006.01) B01D 11/02 (2006.01) C12F 3/06 (2006.01)
Patent
CA 2440333
The present invention deal with a process to obtain a decoction from Vitis labrusca and Vitis skins; process to obtain a hydro-alcoholic and hydro- alcoholic-ethyl acetate obtained from the decoction; pharmaceutical preparations containing the decoction and the before mentioned extracts and therapeutic utilization of the preparations and the prevention and treatment of arterial hypertension and other cardiovascular diseases. The decoctions and the extracts, when administered orally to rats with spontaneous arterial hypertension, hypertension induced by chronically inhibition of nitric oxide synthesis or induced by DOCA-salt administration induced a significant reduction of the high levels of arterial blood pressure. Capsules and tablets were prepared with the decoctions and extracts.
L'invention concerne un procédé de préparation d'une décoction de peaux de Vitis labrusca et de Vitis Vinifera; un procédé de préparation d'acétate hydro-alcoolique et hydro-alcoolique-éthylique à partir de ladite décoction; des préparations pharmaceutiques contenant cette décoction et lesdits extraits, ainsi que l'utilisation thérapeutique de ces préparations dans la prévention et le traitement de l'hypertension artérielle et d'autres maladies cardio-vasculaires. Lorsqu'elles sont administrées per os à des rats souffrant d'hypertension artérielles spontanée, d'hypertension induite par l'inhibition chronique de la synthèse de l'oxyde nitrique ou par l'administration de sel-DOCA, ces décoctions et extraits réduisent de manière importante la pression artérielle élevée. Des capsules et des comprimés ont été préparés à partir de ces décoctions et extraits.
Moffat & Co.
Universidade Do Estado Do Rio de Janeiro
LandOfFree
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