Efficient microcapsule preparation and method of use

Details Efficient microcapsule preparation and method of use Efficient microcapsule preparation and method of use

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 9/52 (2006.01) A61K 31/13 (2006.01) A61K 31/505 (2006.01) A61K 31/565 (2006.01) A61K 33/24 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 51/12 (2006.01) B01F 3/08 (2006.01) B01J 13/02 (2006.01) B01J 13/12 (2006.01) B01J 13/20 (2006.01)

Patent

CA 2092551

2092551 9205866 PCTABS00011 The present invention relates to a highly efficient method of preparing microcapsules suitable for encapsulation or surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of hydrophilic radiodiagnostic agents in 1 µm capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 µm capsules for chemo embolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules.

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