Human c5a-like receptor

Details Human c5a-like receptor Human c5a-like receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2279344

The present invention provides a human C5a-like receptor (HCOR) and polynucleotides which identify and encode HCOR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCOR and a method for producing HCOR. The invention also provides agonists, antibodies, or antagonists specifically binding HCOR, and their use, in the prevention and treatment of diseases associated with expression of HCOR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCOR for the treatment of diseases associated with the expression of HCOR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCOR.

La présente invention porte sur un récepteur humain de type C5a (HCOR) et sur des polynucléotides identifiant et codant HCOR. Cette invention à trait également à des vecteurs d'expression issus du génie génétique et à des cellules hôtes comprenant les séquences d'acide nucléique codant HCOR et à un procédé de production de HCOR. Elle a également trait à des agonistes, des anticorps ou des antagonistes se liant spécifiquement à HCOR, et à leur utilisation dans la prévention et le traitement de pathologies associées à l'expression de HCOR. L'invention a trait de plus à l'utilisation de molécules antisens contre des polynucléotides codant HCOR dans le traitement de pathologies associées à l'expression de HCOR. Elle a encore trait à des dosages diagnostiques mettant en oeuvre le polynucléotide ou des fragments de celui-ci ou son complément, et des anticorps se liant spécifiquement à HCOR.

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