Thiol sulfone metalloprotease inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 323/65 (2006.01) A61K 31/10 (2006.01) A61K 31/17 (2006.01) A61K 31/265 (2006.01) A61K 31/33 (2006.01) A61K 31/4164 (2006.01) A61K 31/426 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/5377 (2006.01) C07C 317/22 (2006.01) C07C 327/22 (2006.01) C07C 327/24 (2006.01) C07C 327/26 (2006.01) C07D 213/34 (2006.01) C07D 213/70 (2006.01) C07D 233/84 (2006.01) C07D 277/36 (2006.01) C07D 295/088 (2006.01) C07D 317/64 (2006.01)

Patent

CA 2260859

This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP- 13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.

Cette invention se rapporte à des inhibiteurs de protéinases (protéases) et plus particulièrement à des inhibiteurs à base de sulfone de thiol pour les métalloprotéases matricielles 13 (MMP-13), à des compositions d'inhibiteurs de protéinases, à des intermédiaires pour la synthèse d'inhibiteurs de protéinases, à des procédés pour la préparation d'inhibiteurs de protéinases et à des procédés pour traiter les états pathologiques associés à une activité pathologique des métalloprotéases matricielles du type MMP-13.

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