A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01)
Patent
CA 2564503
Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
L'invention concerne des méthodes et des compositions permettant de limiter les quantités de génome viral dans une cellule cible. Dans ces méthodes, l'activité d'un ARNmi est inhibée de manière suffisante pour limiter la quantité de génome viral une cellule cible, par exemple, par introduction d'un agent inhibiteur d'ARNmi dans ladite cellule cible. L'invention concerne également des compositions pharmaceutiques, des kits et des systèmes utilisés pour mettre ces méthodes en oeuvre. L'invention est utilisée dans une variété d'applications, notamment, le traitement de sujets souffrant d'un état pathologique à médiation virale, par exemple, un état pathologique induit par l'hépatite C.
Jopling Catherine L.
Lancaster Alissa M.
Sarnow Peter
Smart & Biggar
The Board Of Trustees Of The Leland Stanford Junior University
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