Methods for enhancing binding interactions between members...

Details Methods for enhancing binding interactions between members... Methods for enhancing binding interactions between members...

G - Physics

01

N

G01N 33/53 (2006.01) G01N 1/36 (2006.01) G01N 33/543 (2006.01) G01N 33/553 (2006.01) G01N 33/566 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2359664

Disclosed is a method that improves the efficiency of reactions between specific binding pairs. By translating one member of the pair through a suspension of the second member, or across a surface to which the second member is immobilized, collision and binding frequencies are greatly increased. The resulting increased binding frequency allows for reduced incubation times and lower incubation temperatures. The enhanced collisions are advantageous for both molecular reactions, in which mixing is not always effective, and cellular reactions, in which the cells may be damaged by mixing.

L'invention concerne un procédé qui améliore l'efficacité des réactions entre des paires de liaison spécifique. En traduisant un élément de la paire par suspension du second élément, ou sur toute une surface où le second élément est immobilisé, on accroît considérablement les fréquences de collision et de liaison. La fréquence de liaison accrue résultante autorise des temps et des températures d'incubation réduits. Les collisions améliorées sont avantageuses tant pour des réactions moléculaires dans lesquelles le mixage n'est pas toujours effectif, que pour des réactions cellulaires dans lesquelles les cellules peuvent être endommagées par le mixage.

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