Substituted 4-amino-2-aryltetrahydroquinazolines, their...

Details Substituted 4-amino-2-aryltetrahydroquinazolines, their... Substituted 4-amino-2-aryltetrahydroquinazolines, their...

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01) A61K 31/505 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2362363

The present invention relates to compounds of formula (I) which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of formula (I) have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for the preparation of compounds of formula (I), their use for the therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, and pharmaceutical compositions which comprise a compound of formula (I).

Cette invention concerne des composés qui correspondent à la formule (I) où R<1>, R<2> et R<3> sont tels que décrits dans les revendications. Ces composés consistent en des composés pharmaceutiques actifs et de valeur utilisés dans le traitement et la prévention de maladies telles que les troubles cardio-vasculaires comme une pression sanguine élevée, une angine de poitrine, une insuffisance cardiaque, des thromboses ou l'athérosclérose. Ces composés sont capables de moduler la production endogène de monophosphate de guanosine cyclique (cGMP), et conviennent de manière générale à la thérapie et à la prévention d'états maladifs associés à un déséquilibre de cGMP. Cette invention concerne également des procédés de préparation de ces composés, leur utilisation dans le traitement et la prévention des états maladifs susmentionnés et dans la production de produits pharmaceutiques permettant de les traiter, ainsi que des compositions pharmaceutiques qui comprennent lesdits composés.

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