Hybrid toxins comprising shiga-like toxin subunits fused to...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/108 (2006.01) A61K 39/112 (2006.01) C07K 14/245 (2006.01) C07K 14/25 (2006.01)

Patent

CA 2531441

The present invention relates to a hybrid bacterial toxin subunit, to a hybrid bipartite bacterial toxin and to nucleic acid molecules comprising a nucleotide sequence encoding such bacterial toxins. Furthermore, the invention relates to vaccines comprising said bacterial toxins and to their use in vaccines. Finally, the invention relates to methods for the preparation of such vaccines and to the use of such bacterial toxins for the manufacture of such vaccines.

L'invention concerne une sous-unité de toxine bactérienne hybride, une toxine bactérienne bipartite hybride et des molécules d'acide nucléique comprenant une séquence nucléotidique codant de telles toxines bactériennes. La présente invention porte également sur des vaccins contenant ces toxines bactériennes, sur leur utilisation dans les vaccins, ainsi que sur des procédés pour préparer ces vaccins et sur l'utilisation de telles toxines bactériennes pour produire de tels vaccins.

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