New piperazino-dihydrothienopyrimidine derivatives

Details New piperazino-dihydrothienopyrimidine derivatives New piperazino-dihydrothienopyrimidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 11/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2702518

The invention relates to the novel dihydrothienopyrimidine sulfoxides of formula (I) and to the pharmacologically acceptable salts thereof, wherein X represents SO or SO2, preferably however SO, and wherein R3, R4, R4', R5, R6 and R7 are defined as in claim 1. The invention also relates to pharmaceutical compositions containing said compounds. The novel dihydrothienopyrimidine sulfoxides are suitable for use in the treatment of respiratory or gastrointestinal disorders or diseases, inflammatory diseases of the joints, the skin or the eyes, diseases of the peripheral or central nervous system or cancers.

L'invention concerne de nouveaux sulfoxydes de dihydrothiénopyrimidine de formule (I), ainsi que leurs sels pharmacologiquement compatibles. Dans la formule (I), X représente SO ou SO2, de préférence SO, et R3, R4, R4', R5, R6 et R7 ont la signification indiquée dans la revendication 1. L'invention concerne également des compositions pharmaceutiques contenant ces composés. Ces nouveaux sulfoxydes de dihydrothiénopyrimidine sont appropriés pour le traitement des troubles ou des affections des voies respiratoires ou gastro-intestinales, des maladies inflammatoires des articulations, de la peau ou des yeux, des maladies du système nerveux périphérique ou central ou des maladies cancéreuses.

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