Neuronal progenitors from feeder-free human embryonic stem...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/00 (2006.01)

Patent

CA 2583473

The present invention relates to methods for producing feeder cell-free neuroprogenitor cells (preferably adherent) from embryonic stems cells, preferably human embryonic stem cells, the feeder cell-free neuroprogenitor cells, preferably human cells themselves, as well as methods for producing feeder cell-free samples of neuronal cells, preferably adherent human neuronal cells and the feeder cell-free neuronal cells themselves. Pharmaceutical compositions and methods of treating neurodegenerative diseases as well as the use of the described cells in assay systems is also described.

La présente invention concerne une méthode de production de cellules neuroprogénitrices sans cellules nourricières (de préférence adhérentes) à partir de cellules souches embryonnaires, de préférence humaines, les cellules neuroprogénitrices sans cellules nourricières, de préférence les cellules humaines elles-mêmes, ainsi que des méthodes d'obtention d'échantillons de cellules neuronales sans cellules nourricières, de préférence des cellules neuronales humaines adhérentes et les cellules neuronales sans cellules nourricières elles-mêmes. Sont également décrites des compositions pharmaceutiques t des méthodes de traitement de maladies neurodégénératives ainsi que l'utilisation des cellules susdécrites dans des systèmes de criblage.

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