Process for the preparation of an insulin precursor

Details Process for the preparation of an insulin precursor Process for the preparation of an insulin precursor

C - Chemistry, Metallurgy

07

K

530/3.08, 530/7.

C07K 14/62 (2006.01) C07K 1/107 (2006.01)

Patent

CA 2008245

- 1 - Abstract of the Disclosure: HOE 89/F 021 Process for the preparation of an insulin precursor Preparation of an insulin precursor of the formula I (A-1) (A-6) (A-20) (A-21) (A-11) (A-7) Image (I) (B-1) (B-7) (B-19) (B-30) in which R1 = H or an amino acid or peptide radical which can be split off chemically or enzymatically, R2=OH or an amino acid or peptide radical, X = a radical which bonds the insulin A and B chain, Y = the radical of a genetically encodable amino acid, Z = the radical of a genetically encodable amino acid and A1-A20 and B1-B29 = peptide sequences of insulin which are non-mutated or mutated by replacement of one or more amino acids, by reaction of a precursor in which the disulfide bridges between positions A6 and A11, A7 and B7 and A20 and B19 have not yet been formed, with excess mercaptan in the presence of an organic redox system or at least one organic compound which forms such an organic redox system under the reaction conditions. A particularly preferred organic redox system is the pair of compounds ascorbic acid + dehydroascorbic acid.

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