Composition for the treatment of resistant cancers...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/121 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2651795

The present invention relates to the treatment of therapy-resistant neoplasias. The compounds and methods of the invention are particularly useful for the treatment of taxol-resistant human cancers, particularly cervical and breast cancer. Components of the compositions of the present invention show strong synergy with one another allowing them to be used in relatively low amounts for the treatment of stage IV or recurrent cancer which may have grown resistant to the traditional chemotherapeutic agents. These compositions comprise oridonin.

La présente invention concerne le traitement de néoplasies réfractaires à la thérapie. Les composés ainsi que les méthodes de cette invention sont particulièrement utiles pour le traitement des cancers humains résistants au Taxol, en particulier les cancers du sein et du cerveau. Les composés de cette composition ont une très forte synergie les uns par rapport aux autres ce qui permet de les utiliser à des doses relativement faibles lors du traitement de cancers de stade IV ou de cancers récurrents qui peuvent avoir une résistance plus forte aux agents chimiothérapeutiques traditionnels. Ces compositions contiennent de l'oridonine.

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