C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07K 16/24 (2006.01)
Patent
CA 2497804
It is intended to provide substances efficacious in treating immunopathies in which MCP-1 participates. Using the phage antibody method, scFv having a high affinity for human MCP-1 is obtained. Based on the data concerning the VH chain and the VL chain obtained from this scFv, a human antihuman MCP-1 antibody and a human antihuman MCP-1 antibody fragment are obtained. These antibody and antibody fragment are expected as usable as remedies for inflammation and immunopathies caused by MCP-1.
L'invention concerne des matières efficaces pour traiter des immunopathies dans lesquelles intervient le MCP-1. A l'aide de la méthode des anticorps présentés à la surface des phages, on obtient scFv, qui présente une affinité élevée pour le MCP-1 humain. Sur la base des données concernant la chaîne VH et la chaîne VL obtenues à partir de scFv, on produit un anticorps MCP-1 anti-humain d'origine humaine et un fragment d'anticorps anti-humain d'origine humaine. L'anticorps et le fragment d'anticorps sont présumés utiles pour traiter l'inflammation et les immunopathies provoquées par le MCP-1.
Nakashima Toshihiro
Nishihara Tsukasa
Sugimura Kazuhisa
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Kirby Eades Gale Baker
LandOfFree
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