Methods for preventing or treating acute and chronic pain

Details Methods for preventing or treating acute and chronic pain Methods for preventing or treating acute and chronic pain

A - Human Necessities

61

K

A61K 31/522 (2006.01) A61P 25/02 (2006.01) A61P 29/00 (2006.01) C07D 473/04 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2652038

The present invention is a method for preventing or treating acute and chronic pain. Using an agent to increase the expression or activity of GLT-1, behavioral hypersensitivity is attenuated thereby preventing or treating acute and chronic pain in a subject in need of such treatment. Methods for identifying agents that prevent or treat acute and chronic pain through modulation of the expression or activity of GLT-1 or the GLT-1 pathway are also provided.

La présente invention concerne un procédé de prévention ou de traitement de douleur aiguë et chronique. Au moyen d'un agent pour accroître l'expression ou l'activité de GLT-1, on atténue l'hypersensibilité comportementale assurant ainsi la prévention ou le traitement de douleur aiguë ou chronique chez un sujet qui nécessite un tel traitement. L'invention concerne également des procédés d'identification d'agents qui assurent la prévention ou le traitement de douleur aiguë et chronique grâce à la modulation de l'expression ou de l'activité de GLT-1 ou de la voie de GLT-1.

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