Stabilized maml peptides and uses thereof

Details Stabilized maml peptides and uses thereof Stabilized maml peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 38/02 (2006.01) A61P 35/00 (2006.01) C07K 1/107 (2006.01) C07K 7/08 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2669696

Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.

L'invention concerne des polypeptides réticulés de manière stable associés aux MAML humains. Ces polypeptides réticulés contiennent au moins deux acides aminés modifiés qui forment conjointement une réticulation ou fixation interne qui peut aider à stabiliser la structure secondaire alpha hélicoïdale qui est considérée comme étant importante pour la liaison de peptides MAML au complexe de transcription Notch, un complexe qui comprend ICN et CSL.

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