C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2631938
Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen- binding fragments thereof. The antibodies of the invention are useful in particular for treating autoimmune, inflammatory, cell proliferative and developmental disorders.
La présente invention concerne l'identification des anticorps anti-IL-17 qui sont caractérisés par leur affinité élevée et une faible vitesse de dissociation pour l'IL-17 humaine. Les anticorps de l'invention peuvent être des anticorps chimériques, humanisés ou entièrement humains, des immunoconjugués des anticorps ou des fragments de liaison de l'antigène de ceux-ci. Les anticorps de l'invention sont utilisables en particulier pour le traitement de l'auto-immunité, de l'inflammation, de la prolifération cellulaire et des troubles du développement.
Allan Barrett
Chow Chi-Kin
Huang Lihua
Liu Ling
Lu Jirong
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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