C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C12N 5/00 (2006.01)
Patent
CA 2572938
The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD 16 (Fc.gamma.RIII-A), or other Fcy or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as Fc.epsilon.RI-.gamma.,TCR-.zeta., or to concurrently express interleukin-2 (IL- 2) or other cytokines. Additional methods are disclosed for various assays, assessments, and therapeutic treatments with the modified NK-92 cells.
Cellules tueuses naturelles, NK-92, modifiées pour exprimer un récepteur Fc sur la surface de la cellule, notamment CD 16 (Fc.gamma.RIII-A), ou d'autres récepteurs Fc.gamma. ou Fc. La cellule NK-92 modifiée peut encore être modifiée pour exprimer simultanément une protéine de signalisation accessoire associée, notamment Fc.epsilon.RI-.gamma.,TCR-.zeta., ou exprimer simultanément une interleukine-2 (IL-2) ou d'autres cytokines. Procédés supplémentaires pour différents essais, évaluations et traitements thérapeutiques utilisant les cellules NK-92 modifiées.
Borden Ladner Gervais Llp
Fox Chase Cancer Center
LandOfFree
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