C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2689092
The present invention comprises a new class of compounds capable of modulating the activity of Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula (I) wherein each of A1, A2, A3, A4, A5, A6, A7, A8, A9, bond B, X, rings Z1 and Z2, R1 and R3 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
La présente invention concerne une nouvelle classe de composés qui peuvent moduler l'activité de la Raf kinase et sont donc utiles pour le traitement de maladies médiées par la Raf kinase, dont les mélanomes, les tumeurs et autres affections liées au cancer. Les composés de l'invention présentent la formule (I) dans laquelle A1, A2, A3, A4, A5, A6, A7, A8, A9; la liaison B, X; les noyaux Z1 et Z2; R1 et R3 sont tels que définis dans la description. L'invention concerne en outre des compositions pharmaceutiques, des méthodes de traitement de maladies médiées par la Raf kinase, et des intermédiaires et procédés utiles pour la préparation de composés de l'invention.
Doherty Elizabeth M.
Huang Qi
Liu Gang
Smith Adrian L.
Amgen Inc.
Gowling Lafleur Henderson Llp
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