Xbp1, cd138, and cs1 peptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 37/04 (2006.01) C07K 7/06 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2726804

The disclosure features, inter alia, immunogenic XBP1-, CD138-, and CS1- derived peptides (and pharmaceutical compositions thereof). The peptides can be used in a variety of methods such as methods for inducing an immune response, methods for producing an antibody, and methods for treating a cancer (e.g., a plasma cell disorder such as multiple myeloma or Waldenstrom's macroglobulinemia). The peptides can also be included in MHC molecule multimer compositions and used in, e.g., methods for detecting a T cell in a population of cells.

L'invention porte, entre autres, sur des peptides dérivés de XBP1, CD138 et CS1 immunogènes (et sur des compositions pharmaceutiques de ceux-ci). Les peptides peuvent être utilisés dans une pluralité de procédés tels que les procédés pour induire une réponse immunitaire, les procédés pour produire un anticorps et les procédés pour traiter un cancer (par exemple, un trouble des plasmocytes tel qu'un myélome multiple ou une macroglobulinémie de Waldenstrom). Les peptides peuvent également être inclus dans des compositions multimères de molécules du CMH et utilisés, par exemple, dans des procédés pour détecter un lymphocyte T dans une population de cellules.

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