Imidazolidinonyl aminopyrimidine compounds for the treatment...

Details Imidazolidinonyl aminopyrimidine compounds for the treatment... Imidazolidinonyl aminopyrimidine compounds for the treatment...

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/381 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2671738

The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. wherein: R1 hydrogen, hydroxy, halo, methyl, C1-C2 alkoxy, amino, or rnethylamino; R2 is hydrogen, halo, or cyano; R3 is hydrogen or halo;, R4 is hydrogen, halo, or methyl; provided that at least two of R1, R2, R3, and R4 are hydrogen; R5 is hydrogen, halo, or methyl; or a pharmaceutically acceptable salt thereof.

L'invention concerne de nouveaux composés imidazolidinonyl aminopyrimidine considérés comme ayant une utilisation clinique dans le traitement du cancer par inhibition de Plk1, dans lesquels : R1 est un atome d'hydrogène, un groupe hydroxy, halogéno, méthyle, alcoxy en C1 à C2, amino, ou méthylamino ; R2 est un atome d'hydrogène, un groupe halogéno or cyano ; R3 est un atome d'hydrogène ou un groupe halogéno ;, R4 est un atome d'hydrogène, un groupe halogéno ou méthyle ; à condition qu'au moins deux éléments parmi R1, R2, R3 et R4 soient un atome d'hydrogène ; R5 est un atome d'hydrogène, un groupe halogéno ou méthyle ; ou un sel pharmaceutiquement acceptable de ceux-ci.

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