Ophthalmic compositions containing a polysaccharide/borate...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 47/02 (2006.01) A61K 47/36 (2006.01) A61P 27/04 (2006.01)

Patent

CA 2545947

Topical ophthalmic compositions that form a gel or partial gel upon application to the eye are described. The compositions are particularly useful as artificial tears and ocular lubricants, but may also be utilized for the topical delivery of pharmaceutically active compounds to the eye. The compositions contain a polysaccharide/borate gelling system. The polysaccharides that may be utilized contain cis-diol groups and have a structure that is predominately linear, with a slight degree of branching.

La présente invention a trait à des composition ophtalmologiques topiques formant un gel ou un gel partiel lors de l'application sur l'oeil. Les compositions sont particulièrement utiles comme larmes artificielles et lubrifiants oculaires, mais peuvent également être utilisées pour l'administration topique de composés pharmaceutiquement actifs dans l'oeil. Les compositions contiennent un système gélifiant à base de polysaccharide/borate. Les polysaccharides pouvant être utilisés contiennent des groupes cis-diol et présentent une structure majoritairement linéaire, avec un faible degré de ramification.

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