Targeted polymeric conjugates of cyclosporin and method for...

Details Targeted polymeric conjugates of cyclosporin and method for... Targeted polymeric conjugates of cyclosporin and method for...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2079590

2079590 9213569 PCTABS00014 The structure and the manner of manufacture of polymeric conjugates of cyclosporin, characterized in that they as polymeric carriers contain 40-700 polymerized monomeric units composed from 20-99 % mol. biologically inert hydrophilic units, such as N-(2-hydroxypropyl)methacrylamide, N-vinylpyrrolidone, or acrylic and methacrylic acid in the form of sodium salts, 0.1-25 % mol. units of methacryloylated amino acids or methacryloylated oligopeptides with terminally bound cyclosporin and 0-10 % mol. units of methacryloylated amino acids or oligopeptides, with an antibody bound to them as the determinant of transport to the targeted cells.

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