Polypeptides

Details Polypeptides Polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2382852

A polypeptide (interacting polypeptide) capable of interacting with a Smad polypeptide wherein the interacting polypeptide comprises the amino acid sequence PP(T/N)K and is less than 150 amino acids in length or is not full- length Xenopus or human FAST1 or a fragment thereof, mouse FAST2, Xenopus Milk, Xenopus Mixer or Xenopus Bix2. The Smad polypeptide may be Smad2 or Smad3. The interacting polypeptides are useful in screening assays and in medicine.

La présente invention concerne un polypeptide (polypeptide d'interaction) capable de réagir mutuellement avec un polypeptide Smad, le polypeptide d'interaction comprenant la séquence d'acide aminé PP(T/N)K et comporte moins de 150 acides aminés en longueur ou ne représente pas un Xenopus pleine longueur ou un FAST1 humain ou un fragment de celui-ci, un FAST2 de souris, un Xenopus Milk, un Xenopus Mixer ou un Xenopus Bix2. Le polypeptide Smad peut être un Smad2 ou un Smad3. Les polypeptides d'interaction sont utiles en médecine dans les tests de criblage.

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