C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4433 (2006.01) A61P 3/04 (2006.01)
Patent
CA 2559698
The invention relates to an alkyne compound of general formula (I) in which A, B, W, X, Y, Z, R1 and R2 groups and residuals have the meanings given in claim 1. Drugs containing at least one type of inventive alkyne are also disclosed. The inventive drugs exhibiting an MCH-receptor antagonistic activity are suitable for treating metabolic disturbances and/or eating disorders, in particular adiposity, bulimia, anorexia, hyperphagia and diabetes.
Composés alkyne de formule générale (I) dans laquelle les groupes et restes A, B, W, X, Y, Z, R1 et R2 possèdent les significations figurant dans la revendication 1. La présente invention concerne en outre des médicaments contenant au moins une alkyne selon la présente invention. En raison de leur activité antagoniste du récepteur de l'hormone concentrant la mélanine (MCH), les médicaments selon la présente invention sont appropriés pour traiter des troubles métaboliques et / ou des troubles de l'alimentation, en particulier l'adiposité, la boulimie, l'anorexie, l'hyperphagie et le diabète.
Lehmann-Lintz Thorsten
Lotz Ralf R. H.
Lustenberger Philipp
Mueller Stephan Georg
Roth Gerald Juergen
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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