Targeting of conjugates of poly(ethylene glycol) and...

Details Targeting of conjugates of poly(ethylene glycol) and... Targeting of conjugates of poly(ethylene glycol) and...

A - Human Necessities

61

K

A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232834

A method for delaying onset of insulin dependent diabetes mellitus (IDDM) in an individual predisposed to developing the disease is disclosed. The method comprises administering a composition comprising an immunologically effective monoclonal antibody or fragment thereof against glutamic acid decarboxylase (GAD) coupled to a nonimmunogenic hydrophilic polymer that provides a hydration shell around the monoclonal antibody for inhibiting immune recognition thereof. Poly(ethylene glycol) is a preferred polymer. A method of reducing insulitis in an IDDM patient and a composition therefor are also described.

Procédé visant à retarder l'apparition du diabète sucré insulinodépendant (IDDM) chez un individu prédisposé au développement de cette maladie. Le procédé consiste à administrer une composition comprenant un anticorps monoclonal immunologiquement efficace ou un fragment de celui-ci dirigé contre l'acide glutamique décarboxylase (GAD) couplé à un polymère hydrophile non immunogène qui forme une enveloppe d'hydratation autour de l'anticorps monoclonal en vue d'inhiber la reconnaissance immune de celui-ci. Le poly(éthylène glycol) est un polymère préféré. L'invention se rapporte également à un procédé de réduction de l'insulite chez un patient atteint d'IDDM, et à une composition utilisée dans ce procédé.

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