Use of eflucimibe for the production of a medicament for the...

A - Human Necessities – 61 – K

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Details

A61K 31/167 (2006.01) A61K 9/06 (2006.01) A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/70 (2006.01) A61P 17/08 (2006.01) A61P 17/10 (2006.01)

Patent

CA 2692837

The invention relates to the use of at least one of the compounds (S)-2-dodecylsulfanyl-N-(4-hydroxy-2,3,5-trimethyl-phenyl)-2-phenyl-acetanilide (eflucimibe) of formula (I), (R)-2-dodecylsulfanyl-N-(4-hydroxy-2,3,5-trimethyl-phenyl)-2-phenyl-acetanilide ((R) enantiomer), and the pharmaceutically acceptable salts and solvates thereof for producing a medicament or a dermatological composition for preventing and treating disorders caused by sebaceous gland dysfunction and/or any state or disease related to excess sebum production in humans or animals.

La présente invention a pour objet l'utilisation d'au moins un composé parmi le (S)-2-dodécylsulfanyl-N-(4-hydroxy- 2,3,5-trimethyl-phenyl)-2-phenyl- acétanilide (éflucimibe) de formule (I) : le (R)-2-dodécyl sulfanyl-N-(4-hydroxy-2,3,5-trimethyl- phenyl)-2-phenyl-acétanilide (énantiomère (R)), leurs sels pharmaceutiquement acceptables et leurs solvates pharmaceutiquement acceptables, pour la préparation d'un médicament ou d'une composition dermatologique destiné(e) à prévenir ou à traiter les désordres dus à un dysfonctionnement des glandes sébacées et/ou tout état ou pathologie lié à une surproduction de sébum chez l'homme ou l'animal.

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