Use of nateglinide alone or in combination for the treatment...

Details Use of nateglinide alone or in combination for the treatment... Use of nateglinide alone or in combination for the treatment...

A - Human Necessities

61

K

A61K 31/198 (2006.01) A61K 45/00 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 13/12 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2403442

Drugs containing postcibal hypoglycemics as the active ingredient which are efficacious in preventing, ameliorating and treating complications of diabetes, neuropathy, etc. In particular, D-phenylalanine derivatives such as nateglinide are useful as oral drugs. These excellent drugs, methods of using the same (for example, administration for treating the above diseases, etc.), utilization of postcibal hypoglycemics in the production of these drugs, etc. are provided. The above-described effects of preventing, ameliorating and treating the complications can be further enhanced by adding at least one member selected from among hypotensive agents, peripheral circulation improving agents and remedies for hyperlipemia to the above drugs or combining the same with the postcibal hypoglycemics.

L'invention se rapporte à des médicaments contenant en tant que principe actif des hypoglycémiques post prandiaux qui sont efficaces s'agissant de prévenir, améliorer et traiter les complications du diabète, des neuropathies, etc. Les dérivés de D-phénylalanine tels que le natéglinide s'avèrent particulièrement utiles en tant que médicaments destinés à l'administration orale. L'invention se rapporte à ces excellents médicaments, à des procédés d'utilisation de ces médicaments (par exemple, leur administration aux fins du traitement des maladies ci-dessus, etc.), et à l'utilisation d'hypoglycémiques post prandiaux pour la production de ces médicaments, etc. Les effets décrits ci-dessus et concernant la prévention, l'amélioration et le traitement de ces complications, peuvent être renforcés au moyen de l'addition, aux médicaments ci-dessus, d'au moins un élément sélectionné parmi des agents hypotenseurs, des agents améliorant la circulation périphérique et des remèdes traitant l'hyperlipidémie, ou par combinaison de ces médicaments auxdits hypoglycémiques postprandiaux.

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