Supercritical fluid extraction process for tissue preparation

A - Human Necessities – 61 – L

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A61L 2/02 (2006.01) A61L 2/00 (2006.01) A61L 2/18 (2006.01) A61L 27/36 (2006.01)

Patent

CA 2462717

The present invention provides methods for preparing tissue for incorporation into xenografts and bioprosthetic devices. The methods of the invention make use of supercritical fluids to remove infectious materials and chemical agents from tissues, as well as to permeate a tissue with a chemical agent (e.g. tanning, cross-linking, and bioactive agents).

L'invention concerne des procédés de préparation de tissus destinés à être incorporés dans des dispositifs de xénogreffe et de bioprothèse. Les procédés selon l'invention font usage de fluides supercritiques en vue d'éliminer des matières infectieuses et des agents chimiques des tissus, ainsi que d'imprégner un tissu par un agent chimique (par exemple, agent de tannage, agent de réticulation et agent bioactif).

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