C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 39/002 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 7/01 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2237818
The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised againt such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
La présente invention concerne des protéines du facteur inhibiteur de la migration de macrophages (MIF) d'helminthes parasitaires, de molécules d'acides nucléiques du MIF d'helminthes parasitaires, y compris celles codant lesdites protéines du MIF, des anticorps developés contre lesdites protéines du MIF, et des composés inhibant l'activité du MIF d'helminthes parasitaires. La présente invention comprend également des procédés d'obtention de ces protéines, de ces molécules d'acide nucléique, de ces anticorps et de composés inhibiteurs. De plus, l'invention concerne des compositions thérapeutiques comprenant ces protéines, molécules d'acide nucléique, anticorps et/ou composés inhibiteurs, ainsi que l'emploi de ces compositions thérapeutiques pour protégér des animaux contre des maladies provoquées par des helminthes parasitaires.
Brandt Kevin S.
Tripp Cynthia Ann
Wisnewski Nancy
Heska Corporation
Johnson Ernest Peter
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