A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A01N 43/04 (2006.01) C07K 14/075 (2006.01) C12N 15/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2327545
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell- binding protein. The present invention generates an adenovirus with modified fiber gene such that novel tropism is achieved. This recombinant adenovirus has a fiber gene modified in the HI loop domain.
L'invention concerne un dispositif permettant de modifier le tropisme de vecteurs adénoviraux recombinés à l'aide de méthodes génétiques permettant de modifier la protéine de liaison de cellules des fibres adénovirales. L'invention concerne également un gène de fibre modifié de manière à obtenir un nouveau tropisme. L'adénovirus recombiné présente un gène de fibre modifié dans le domaine de boucle HI.
Curiel David T.
Dmitriev Igor
Krasnykh Victor N.
Borden Ladner Gervais Llp
Uab Research Foundation
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