Formulation of insoluble small molecule therapeutics in...

A - Human Necessities – 61 – K

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A61K 47/24 (2006.01) A61K 9/127 (2006.01) A61K 31/505 (2006.01) A61K 31/5377 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2631875

The present invention provides formulations containing at least one unsaturated amphiphilic lipid and an amphipathic or hydrophobic drug and methods of making these formulations. In particular, the present invention provides formulations of at least one unsaturated phospholipid and an amphipathic or hydrophobic pyrimidine drug, methods of making these formulations and the use of such formulations in a variety of contexts, including, for example, the treatment of proliferative disorders, such as tumors and cancers.

La présente invention concerne des formulations contenant au moins un lipide amphiphile insaturé et un médicament amphipathique ou hydrophobe ainsi que des procédés de fabrication de ces formulations. En particulier, la présente invention concerne des formulations d'au moins un phospholipide insaturé et un médicament à base de pyrimidine amphipathique ou hydrophobe, des procédés de fabrication de ces formulations et l'utilisation de telles formulations dans divers contextes, comprenant, par exemple, le traitement de troubles proliférants, tels que des tumeurs et des cancers.

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