Secreted ap2 and methods of inhibiting same

Details Secreted ap2 and methods of inhibiting same Secreted ap2 and methods of inhibiting same

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01) A61P 25/28 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2753991

A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.

L'invention porte sur une méthode permettant d'atténuer un symptôme d'un trouble clinique caractérisé par une aP2 circulante anormalement élevée. La méthode consiste à administrer à un sujet un inhibiteur d'aP2 sécrétée, de la sécrétion d'aP2, ou un agent bloquant aP2 dans le sérum. Par exemple, l'intolérance au glucose est réduite à la suite de l'administration d'un tel inhibiteur ou agent. Des compositions données à titre d'exemple inhibent la sécrétion cellulaire d'aP2 ou se lient à l'aP2 circulante, réduisant ainsi le taux ou l'activité d'aP2 dans le sang ou le sérum.

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