Chloral-free dca in oligonucleotide synthesis

Details Chloral-free dca in oligonucleotide synthesis Chloral-free dca in oligonucleotide synthesis

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2480725

A process of manufacturing oligonucleotides includes a 5'- deblocking step in which the 5 - blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.

L'invention concerne un procédé de fabrication d'oligonucléotides comprenant une étape de déblocage en 5' dans laquelle le groupe de blocage en 5 est supprimé avec de l'acide dichloroacétique qui est sensiblement dépourvu de chloral. Ce procédé convient pour la fabrication d'oligonucléotides qui sont sensiblement dépourvus d'adduits de chloral.

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