Substituted indoles and azaindoles as angiotensin ii...

Details Substituted indoles and azaindoles as angiotensin ii... Substituted indoles and azaindoles as angiotensin ii...

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) C07D 209/42 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2135605

2135605 9323391 PCTABS00028 Compounds of formula (I), (II), or (III) wherein: R1 is lower alkyl when R2 is V; or R2 is lower alkyl when R1 is V; wherein: V is (A); R3 is hydrogen or lower alkyl; X is hydrogen, lower alkyl, halogen, -C(O)CF3, -CO2R4, or -C(O)NR5R6; Y is hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, or -CO2R4; Z is hydrogen, lower alkyl, lower alkoxy, or halogen; with the proviso that Y and Z cannot be attached to the nitrogen atom in formula (II); in which R4 is hydrogen or lower alkyl; R5 is hydrogen, lower alkyl, or -CH2CO2R4; R6 is hydrogen or lower alkyl; or R5 and R6 taken together with the nitrogen to which they are attached represent a heterocycle; R7 is (B); (C); (D); (E); (F); (G); (H) or (J); in which: R8 is -CO2H or 1H-tetrazol-5-yl; and W is oxygen, sulfur, or -NR-, wherein R is hydrogen or lower alkyl; and the pharmaceutically acceptable salts thereof, exhibit useful pharmacological properties, and are particularly useful as angiotensin (II) antagonists.

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