C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/092 (2006.01) A61K 31/135 (2006.01) A61K 31/21 (2006.01) A61K 31/395 (2006.01) C07C 43/295 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 217/20 (2006.01) C07C 309/65 (2006.01) C07D 207/06 (2006.01)
Patent
CA 2170337
The present invention provides pharmaceutically active compounds formula I Image I wherein R1 is -H, -OH, -O(C1-C4 alkyl), -ococ6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6 alkyl); R2 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C2-C6 alkyl), or halo; R3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1- pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1- hexamethyleneimino; and n is 2 or 3; and or a pharmaceutically acceptable salt thereof. Also provided are compounds of formula Image wherein R1a is -H or -OR5 in which R5 is a hydroxy protecting group. R2a is -H, halo, or -OR6 in which R6 is a hydroxy protecting group; and R4 is -OH or -CHO; or a pharmaceutically acceptable salt thereof. Further provided are pharmaceutical compositions of compounds of formula I, and methods of using formula I compounds for, inter alia, alleviating the symptoms of post menopausal syndrome and hormonally-dependent cancer, particularly, breast cancer.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
Naphthyl compounds, intermediates, compositions, and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Naphthyl compounds, intermediates, compositions, and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Naphthyl compounds, intermediates, compositions, and methods will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2057055